In silico computation of coagulation factor II: a potential water treatment agent against gram negative bacteria

Water, as one of the main sources life, is an important aspect to public health and safety. Up until now there have been many concerns about water pollution especially in developing countries. Heavy polluted that not treated well could cause concerning diseases can lead deaths. Contaminants are chemical, physical, biological origins commonly found these sources. Gram negative bacteria (GNB) seen develop multiple drug antibiotic resistance, causing more fatal infections. This has become a major concern it makes treatment challenging. Our study investigates human coagulation factor II responsible for blood clotting possible method against GNB. By investigating protein interaction with several bacterial lipopolysaccharides proteins calculating binding affinity interaction, results show lower compared previously studied VII. shows possibilities hydrolyse gram-negative act potential GNBs.